Topical Antiinflammatory and antipruritic Drugs
STEP 2: Indications of Topical Anti inflammatory and Antipruritic Drugs:
Topical anti-inflammatory preparations include betamethazone, hydrocortisone, clobetasol proprionate. They are used in management of: Inflammatory conditions of the skin Contact dermatitis Insects sting Eczema Psoriasis.
Topical antipruritic agents include;calamine, dithranol, tretionin acid, para amino benzoic acid and calciprotrial.
They are used in the management of Pruritus associated with: Mild eczematous dermatoses,Pruritus associated with atopic dermatitis, Lichen simplex chronicus.
STEP 3: Contraindication of Topical Anti inflammatory and Antipruritics Drugs:
Topical anti-inflammatory preparations are contraindicated to:
Those who demonstrate hypersensitivity to them.
In untreated infections .Wide spread plaque psoriasis.
Topical antipruritic are contraindicated to: Acute exudative dermatoses
STEP 4: Dose, Dosage and Course of Topical Anti inflammatory and Antipruritic Drug:
Topical anti-inflammatory preparations:
Topical preparations should be applied once daily.
Topical antipruritic:
Topical application of the cream should be performed four times daily for up to 8 days of therapy.
STEP 5: Side Effects and Adverse Effects of Topical Anti inflammatory and Antipruritic Drug.
Topical anti-inflammatory preparations: (corticosteroids) :
Skin atrophy, Purpura ,Ecchymosis Steroid rosacea, Erythema Perioral dermatitis, Steroid acne Hypopigmentation ,Hypertrichosis Allergic contact dermatitis.
Topical antipruritic:
Transient burning, Stinging,Drowsiness Rash,Irritation
STEP 6: Interaction and Precaution of Topical Anti inflammatory and Antipruritic Drug:
Topical anti-inflammatory preparations:
Avoid prolonged use on the face and in the children.
Topical antipruritic:
Interact tricyclic antidepressants.
Avoid near eyes Avoid in broken skin.
Step 7: Key Points:
Topical anti inflammatory are used for the inflammatory condition of the skin. Topical antipruritic are used for pruritus condition.
The topical anti-inflammatory is contraindicated untreated infection and hypersensitivity.
The topical antipruritic are contraindicated in acute exudative dermatoses.
STEP 8:References
Ministry of Health and Social Welfare. ( 2013).
Standard Treatment Guidelines & National Essential Medicines List Tanzania Mainland (4th ed.). Dar es salaam, Tanzania government printers.
Robert L. T., Gary C. Y., Gary R. M., Barbara G. W., Michael, L.. (2014). Pharmacotherapy: A Pathophysiologic Approach (9th ed.). New York, McGraw-Hill Education. Sally S.R., Jeanne C.S. (2000). Introductory Clinical Pharmacology (6th ed) New York, Lippincott Williams and Wilkins. School of Pharmaceutical sciences. (2011).
Tanzania Pharmaceutical Handbook (2nd ed.). Dar es Salaam, ARDHI University press.
The Royal Pharmaceutical Society of Great Britain. (2007).
Martindale: The Extra Pharmacopoeia (5TH ed). London, pharmaceutical press.
The Royal Pharmaceutical Society of Great Britain. (2009).
British National Formulary (59th ed). London, BMJ Group and RPS Publishing.
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